9th International Conference on Structural Biology: Lets Gear the Future with Structural Biology
ConferenceSeries Ltd welcomes you to attend the 9th International Conference on Structural Biology during September 18-20, 2017 at Zurich, Switzerland. This is an excellent opportunity for the delegates from Universities and Institutes to interact with the world class Scientists. The main theme of the conference is “Let’s Gear the Future with Structural Biology”.
Structural Biology 2017 will be a global platform for sharing information and ability from both scientific and industrial group. The meeting goes for uniting the academicians, scientists, instructors, business pioneers, investors and young researchers to a global stage where they can showcase their novel research and contributions in the field of structural biology and biophysics.
Structural Biology 2017 mainly emphasizes on methods such as X-ray diffraction, NMR, electron microscopy, computational approaches, cell signalling and cancer research.
Track-1 3D Structure Determination
Biomolecules are very small to see in detail even by most cutting-edge light microscopes. The methods that the structural biologists use to determine their structures in general involve the measurements on huge numbers of identical molecules at the same time. Some of the best methods include X-ray crystallography, Cryo-Electron Microscopy and Nuclear Magnetic Resonance. Very often scientists use them to study the “native states” of biomolecules.
Track-2 Computational Approaches in Structural Biology
Computational approaches are a boon for structural biology. In general the structure of molecules is determined by experimental methods is both time intense and cost effective. To overcome these constraints, computational approaches like ab-initio modelling, homology modeling and threading method are used.
Track-3 Hybrid Approaches for Structure Prediction
Structural bioinformatics is an exceptionally cost effective solution for protein structure determination. Purely computational prediction methods, like ab initio fragment assembly, advanced fold recognition, composite approaches, and molecular docking are regularly applied today to extend our understanding of protein structures. However, predicted structures are not given the same reliance as their experimental complements. Hybrid approaches are a means to overcome these limitations; by incorporating limited experimental measurements, reliable structures can be computed and unlikely predictions eliminated. Hybrid approaches take advantage of data derived from a wide range of different biophysical and biochemical methods. These methods are of growing interest in current researches of structural biology.
Sequencing meets structural biology is a dedicated track to show how the recently developed methods are used to determine the structure of molecules. This approach proves itself helpful in a more efficient way. Synergistic use of three-dimensional structures and deep sequencing is done to realize the effect of personalized medicine.
Track-5 Structural Biology Databases
A database is a structured collection of data. In the field of structural biology enormous research is being done and as a result massive data is being produced. In order to pile the data in an organized manner, bioinformatics databases are used. Various databases have been created to store biological data, such as sequence databases, structure databases, signalling pathway databases, etc. In the field of structural biology, the mainly used databases are Protein Data Bank (PDB), Electron Microscopy Data Bank, Protein Structure Classification Database (CATH) and Structural Classification of Protein (SCOP).
Track-6 Signalling Biology
Regulation of gene expression comprises a comprehensive range of mechanisms that are used by cells to regulate the production of specific gene products, and is familiarly termed as gene regulation. Sophisticated programs of gene expression are extensively observed in biology, for example to trigger developmental pathways, adapt to new food sources, or respond to environmental stimuli. Essentially any step of gene expression can be modulated, from transcription initiation to post translation modification of a protein.
Track-7 Molecular Modelling and Dynamics
Molecular modelling and simulation embraces all the hypothetical methods and computational procedures used to mimic the behaviour of macromolecules. These techniques are used in diverse fields of drug design, computational chemistry, materials science and computational biology for studying macromolecular systems ranging from small to large biological systems. Simplest calculations can be achieved by hand, but certainly computers are essential to perform molecular modelling of reasonably sized system. Molecular simulation on the other hand uses powerful computers to simulate the interactions between atoms and to understand the properties of materials. Such simulations involve methods that range from very detailed quantum mechanical calculations on atoms to coarse-grained classical dynamics of large groups of molecules on a timescale of milliseconds or longer.
Track-8 Drug Designing
Drug design is also referred as rational drug design. It is an inventive process to find new medication centred on the knowledge of biological target. Drug is most commonly a small molecule that inhibits or activates the function of a biomolecule, which in turn outcomes in a therapeutic benefit to the patient. Drug design commonly but not essentially relies on computational techniques. This type of modelling is often mentioned to as computer-aided drug design. Drug design that depends on the knowledge of the 3D structure of the target is known as structure-based drug design. The main methods available for drug design are structure based drug design and ligand based drug design.
Track-9 Frontiers in Structural Biology
The main focus of a structural biologist is protein structure determination and drug design. Protein plays an important role in human body. Living things would not exist without proteins. Proteins are involved in all aspects of living things. Several proteins provide structure to cells; others tend bind to and carry vital molecules all through the body. Some proteins are involved in biochemical reactions in the body which are termed as enzymes. Others are involved in muscle contractions and immunity. Structure determination of proteins has always been a challenging filed. The complex areas in the field include viruses, pathogens, membrane proteins and signalling pathways. Novel progressions are being done in the arenas of nano patterning and multi scale modelling of cell signalling proteins.
Track-10 Structural Biology in Cancer Research
Major part of research is being carried out in the area of cancer. The main aim is to design and discover novel and effective drugs to cure the disease. Structural biology combined with molecular modelling mainly aims at drug designing. Subsequently, numerous team leaders in Structural biology carry out cancer research to accelerate the exploitation of molecular understanding of biomolecules in the advancement of novel cancer therapies.
Track-11 Structural Biology Complexity Arenas
Structural biology aims at understanding biomolecules at atomic level. All most all aspects in structural biology research seem to be complex. Researchers have been proven to be successful in solving many of the complexities like determination of protein structures, functional annotations and drug designing. Though structures of proteins are solved on a huge scale, the gap between available sequence data and structure data is enormous. Bridging this gap is one of the main challenges. In the current research, some of the most complex areas are protein folding, catching the complication of dynamic nanomachines and signalling networks, understanding the intrinsically disordered proteins.
Track-12 Recent Advances in Structural Biology
Structural biology is one of the expanding fields. In the course of time many advances have taken place. Huge number of solved structures has amplified rapidly. The field of drug design and drug discovery has been advanced. Functional annotations are another field where progressions are being seen. Alterations in order to improve the effectiveness of prevailing tools can also be noted. Remarkable advances can be seen in the areas of imaging technologies and advancement of hybrid methods to understand the structure and function of proteins.